Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Huluwa phosphorylation switch regulates embryonic axis induction.

Nature communications - 19 Nov 2024

Li Yao, Yan Yun, Gong Bo, Zheng Qianwen, Zhou Haiyan, Sun Jiarui, Li Mingpeng, Wang Zhao, Li Yaohui, Wan Yunjing, Chen Weixi, Qi Shiqian, Mo Xianming, Meng Anming, Xiang Bo, Chen Jing

Abstract excerpt

Embryonic axis formation is essential for patterning and morphogenesis in vertebrates and is tightly regulated by the dorsal organizer. Previously, we demonstrated that maternally derived Huluwa (Hwa) acts as a dorsal determinant, dictating axis formation by activating β-catenin signaling in zebrafish and Xenopus. However, the mechanism of activation and fine regulation of the Hwa protein remains unclear. Through...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Patterning
Share to Cyclin-Dependent Kinases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Axin Protein

Share to beta Catenin

Share to Embryo, Nonmammalian

Share to Xenopus Proteins

Share to Zebrafish

Share to Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 39562571
DOI: 10.1038/s41467-024-54450-4
PMCID: PMC11576741

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Huluwa phosphorylation switch regulates embryonic axis induction.PMID 39562571Read ↗

Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling.Semantic proximity Read ↗

Akirin links twist-regulated transcription with the Brahma chromatin remodeling complex during embryogenesis.Semantic proximity Read ↗

Critical role of WW domain phosphorylation in regulating phosphoserine binding activity and Pin1 function.Semantic proximity Read ↗

Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryos.Semantic proximity Read ↗

Greatwall-Endos-PP2A/B55Twins network regulates translation and stability of maternal transcripts in the Drosophila oocyte-to-embryo transition.Semantic proximity Read ↗

Phosphorylation and transactivation of Pax6 by homeodomain-interacting protein kinase 2.Semantic proximity Read ↗

ADNP promotes neural differentiation by modulating Wnt/β-catenin signaling.Semantic proximity Read ↗

Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin.Semantic proximity Read ↗

The type I serine/threonine kinase receptor Alk8/Lost-a-fin is required for Bmp2b/7 signal transduction during dorsoventral patterning of the zebrafish embryo.Semantic proximity Read ↗

The Drosophila p38 MAPK pathway is required during oogenesis for egg asymmetric development.Semantic proximity Read ↗

Protein encoded by the Axin(Fu) allele effectively down-regulates Wnt signaling but exerts a dominant negative effect on c-Jun N-terminal kinase signaling.Semantic proximity Read ↗

Histone acetyltransferase Enok regulates oocyte polarization by promoting expression of the actin nucleation factor spire.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.