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Article

Histone acetyltransferase Enok regulates oocyte polarization by promoting expression of the actin nucleation factor spire.

Genes & development - 15 Dec 2014

Huang Fu, Paulson Ariel, Dutta Arnob, Venkatesh Swaminathan, Smolle Michaela, Abmayr Susan M, Workman Jerry L

Abstract excerpt

KAT6 histone acetyltransferases (HATs) are highly conserved in eukaryotes and have been shown to play important roles in transcriptional regulation. Here, we demonstrate that the Drosophila KAT6 Enok acetylates histone H3 Lys 23 (H3K23) in vitro and in vivo. Mutants lacking functional Enok exhibited defects in the localization of Oskar (Osk) to the posterior end of the oocyte, resulting in loss of germline...

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Share to Acetylation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryo, Nonmammalian

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Identifiers

PMID: 25512562
DOI: 10.1101/gad.249730.114
PMCID: PMC4265678

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