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Article

The STRIPAK signaling complex regulates dephosphorylation of GUL1, an RNA-binding protein that shuttles on endosomes.

PLoS genetics - 1 Sept 2020

Stein Valentina, Blank-Landeshammer Bernhard, Müntjes Kira, Märker Ramona, Teichert Ines, Feldbrügge Michael, Sickmann Albert, Kück Ulrich

Abstract excerpt

The striatin-interacting phosphatase and kinase (STRIPAK) multi-subunit signaling complex is highly conserved within eukaryotes. In fungi, STRIPAK controls multicellular development, morphogenesis, pathogenicity, and cell-cell recognition, while in humans, certain diseases are related to this signaling complex. To date, phosphorylation and dephosphorylation targets of STRIPAK are still widely unknown in microbial...

Topics

Cell Nucleus
Endosomes
Fruiting Bodies, Fungal
Fungal Proteins
Hyphae
Microscopy, Fluorescence
Multiprotein Complexes
Mutation
Phosphoproteins
Phosphorylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Subunits

Proteomics

RNA-Binding Proteins

Signal Transduction

Sordariales

Source

Open in PubMed Open full text

Identifiers

PMID: 32997654
DOI: 10.1371/journal.pgen.1008819
PMCID: PMC7550108

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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The STRIPAK signaling complex regulates dephosphorylation of GUL1, an RNA-binding protein that shuttles on endosomes.PMID 32997654Read ↗

The STRIPAK signaling complex regulates phosphorylation of GUL1, an RNA-binding protein that shuttles on endosomesSemantic proximity Read ↗

STRIPAK, a Key Regulator of Fungal Development, Operates as a Multifunctional Signaling HubSemantic proximity Read ↗

Phosphoproteomic analysis of STRIPAK mutants identifies a conserved serine phosphorylation site in PAK kinase CLA4 to be important in fungal sexual development and polarized growthSemantic proximity Read ↗

iTRAQ-based proteomic and phosphoproteomic analyses of STRIPAK mutants from the fungus <i>Sordaria macrospora</i> identifies a conserved serine phosphorylation site in PAK kinase CLA4 to be important for sexual development and polarized growthSemantic proximity Read ↗

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The Cryptococcus neoformans STRIPAK complex controls genome stability, sexual development, and virulenceSemantic proximity Read ↗

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