Host-functionalization of macrin nanoparticles to enable drug loading and control tumor-associated macrophage phenotype.

Abstract excerpt

Macrophages are critical regulators of the tumor microenvironment and often present an immuno-suppressive phenotype, supporting tumor growth and immune evasion. Promoting a robust pro-inflammatory macrophage phenotype has emerged as a therapeutic modality that supports tumor clearance, including through synergy with immune checkpoint therapies. Polyglucose nanoparticles (macrins), which possess high macrophage...

Topics

Join the communities discussing this publication.

• Mice
• Nanoparticles
• Neoplasms
• Pharmaceutical Preparations
• Phenotype