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Ascorbate peroxidase modulation confirms key role in Leishmania infantum oxidative defence

18 Nov 2024

Abstract excerpt

Abstract Background Ascorbate peroxidase (APX) has emerged as a promising target for chemotherapy because of its absence in humans and crucial role in the antioxidant defence of trypanosomatids. APXs, which are class I haeme-containing enzymes, reduces hydrogen peroxide using ascorbate to produce water and monodehydroascorbate, thereby preventing cell damage caused by H2O2. Methods We aimed to create an...

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PMID: 39558417
DOI: 10.1186/s13071-024-06562-5

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