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Addressing anemia severity in antimony-resistant <i>Leishmania donovani</i> infection at the nexus of oxidative outburst and iron transit

2024-03-04

Abstract excerpt

Despite the withdrawal of pentavalent-antimonials in treating Visceral leishmaniasis for more than a decade, recent clinical isolates of Leishmania donovani (LD) exhibit unresponsiveness towards pentavalent-antimony (LD-R). This antimony-unresponsiveness points towards a genetic adaptation that underpins LD-R’s evolutionary persistence and superiority over sensitive counterparts. This study highlights LD’s respon...

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Literature Corpus work
44b8ca98-6a29-5d82-9b8a-118c258dc650
DOI
10.1101/2024.03.04.583250
Open publication

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Addressing anemia severity in antimony-resistant <i>Leishmania donovani</i> infection at the nexus of oxidative outburst and iron transitDOI 10.1101/2024.03.04.583250
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