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Article

A self-eliminating allelic-drive reverses insecticide resistance in Drosophila leaving no transgene in the population.

Nature communications - 17 Nov 2024

Auradkar Ankush, Corder Rodrigo M, Marshall John M, Bier Ethan

Abstract excerpt

Insecticide resistance (IR) poses a significant global challenge to public health and welfare. Here, we develop a locally-acting unitary self-eliminating allelic-drive system, inserted into the Drosophila melanogaster yellow (y) locus. The drive cassette encodes both Cas9 and a single gRNA to bias inheritance of the favored wild-type (1014 L) allele over the IR (1014 F) variant of the voltage-gated sodium ion...

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Source

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Identifiers

PMID: 39551783
DOI: 10.1038/s41467-024-54210-4
PMCID: PMC11570635

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