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Article

Treatment Strategies Considering Micro-Environment and Clonal Evolution in Multiple Myeloma

8 Jan 2021

Abstract excerpt

Multiple myeloma is an uncurable hematological malignancy because of obtained drug resistance. Microenvironment and clonal evolution induce myeloma cells to develop de novo and acquired drug resistance, respectively. Cell adhesion-mediated drug resistance, which is induced by the interaction between myeloma and bone marrow stromal cells, and soluble factor-mediated drug resistance, which is induced by cytokines...

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PMID: 33435539
DOI: 10.3390/cancers13020215

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