Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel small-molecule agonist of PPAR-γ potentiates an anti-inflammatory M2 glial phenotype.

Neuropharmacology - 1 Oct 2016

Song Gyun Jee, Nam Youngpyo, Jo Myungjin, Jung Myungsu, Koo Ja Young, Cho Wansang, Koh Minseob, Park Seung Bum, Suk Kyoungho

Abstract excerpt

Neuroinflammation is a key process for many neurodegenerative diseases. Activated microglia and astrocytes play an essential role in neuroinflammation by producing nitric oxide (NO), inflammatory cytokines, chemokines, and neurotoxins. Therefore, targeting glia-mediated neuroinflammation using small-molecules is a potential therapeutic strategy. In this study, we performed a phenotypic screen using microglia...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Inflammatory Agents
Share to Cell Survival

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dose-Response Relationship, Drug

Share to Inflammation Mediators

Share to Neuroglia

Share to PPAR gamma

Share to Small Molecule Libraries

Source

Identifiers

PMID: 27288982
DOI: 10.1016/j.neuropharm.2016.06.009

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel small-molecule agonist of PPAR-γ potentiates an anti-inflammatory M2 glial phenotype.PMID 27288982Read ↗

PPAR-γ promotes the polarization of rat retinal microglia to M2 phenotype by regulating the expression of CD200-CD200R1 under hypoxia.Semantic proximity Read ↗

Ursolic acid promotes microglial polarization toward the M2 phenotype via PPARγ regulation of MMP2 transcription.Semantic proximity Read ↗

Inhibition of the TLR4/NF-κB pathway promotes the polarization of LPS-induced BV2 microglia toward the M2 phenotype.Semantic proximity Read ↗

Adjuvant Cannabinoid Receptor Type 2 Agonist Modulates the Polarization of Microglia Towards a Non-Inflammatory Phenotype in Experimental Pneumococcal Meningitis.Semantic proximity Read ↗

4R-cembranoid suppresses glial cells inflammatory phenotypes and prevents hippocampal neuronal loss in LPS-treated mice.Semantic proximity Read ↗

Rg1 improves LPS-induced Parkinsonian symptoms in mice via inhibition of NF-κB signaling and modulation of M1/M2 polarization.Semantic proximity Read ↗

Oxymatrine inhibits neuroinflammation byRegulating M1/M2 polarization in N9 microglia through the TLR4/NF-κB pathway.Semantic proximity Read ↗

Muscone promotes functional recovery by facilitating microglia polarization into M2 phenotype through PPAR-γ pathway after ischemic stroke.Semantic proximity Read ↗

Phytocannabinoids Reduce Inﬂammation of Primed Macrophages and Enteric Glial CellsSemantic proximity Read ↗

Farrerol attenuates MPP+‐induced inflammatory response by TLR4 signaling in a microglia cell lineSemantic proximity Read ↗

Inhibition of microglia activation as a phenotypic assay in early drug discovery.Semantic proximity Read ↗

Modulation of cannabinoid receptor 2 alters neuroinflammation and reduces formation of alpha-synuclein aggregates in a rat model of nigral synucleinopathySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.