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Article

The contribution of attention-deficit/hyperactivity disorder polygenic load to metabolic and cardiovascular health outcomes: a large-scale population and sibling study.

Translational psychiatry - 13 Nov 2024

Du Rietz Ebba, Xie Tian, Wang Rujia, Cheesman Rosa, Garcia-Argibay Miguel, Dong Zihan, Zhang Jia, Niebuur Jacobien, Vos Melissa, Snieder Harold, Larsson Henrik, Hartman Catharina A

Abstract excerpt

Emerging evidence suggests that ADHD is associated with increased risk for metabolic and cardiovascular (cardiometabolic) diseases. However, an understanding of the mechanisms underlying these associations is still limited. In this study we estimated the associations of polygenic scores (PGS) for ADHD with several cardiometabolic diseases and biomarkers. Furthermore, we investigated to what extent the PGS effect...

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PMID: 39537628
DOI: 10.1038/s41398-024-03178-2
PMCID: PMC11561358

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