Article
Shared genetic influences between attention-deficit/hyperactivity disorder (ADHD) traits in children and clinical ADHD.
Journal of the American Academy of Child and Adolescent Psychiatry - 1 Apr 2015
Stergiakouli Evie, Martin Joanna, Hamshere Marian L, Langley Kate, Evans David M, St Pourcain Beate, Timpson Nicholas J, Owen Michael J, O'Donovan Michael, Thapar Anita, Davey Smith George
Abstract excerpt
OBJECTIVE: Twin studies and genome-wide complex trait analysis (GCTA) are not in agreement regarding heritability estimates for behavioral traits in children from the general population. This has sparked a debate on the possible difference in genetic architecture between behavioral traits and psychiatric disorders. In this study, we test whether polygenic risk scores associated with variation in...
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