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Article

Comparing one stage, chromogenic assay results and discrepancies with bleeding phenotype and genetic variants in females with hemophilia A.

Journal of thrombosis and haemostasis : JTH - 1 Feb 2025

Srivaths Lakshmi, Larson Joanna, Saroukhani Sepideh, Said Mohammed, Brown Deborah, Rodriguez Nidra, Menon Neethu, Escobar Miguel

Abstract excerpt

BACKGROUND: Increasing evidence in females with hemophilia A has shown significant bleeding symptoms. Accurate factor (F) VIII activity (FVIII:C) measurement is essential to assign correct diagnosis and severity. Assay discrepancies reported in male patients with hemophilia A are not well studied in females. OBJECTIVES: Our research sought to assess the association of FVIII:C levels by one-stage versus...

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PMID: 39536816
DOI: 10.1016/j.jtha.2024.10.030

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