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Genetics and Hemostatic Potential in Persons with Mild to Moderate Hemophilia A with a Discrepancy between One-Stage and Chromogenic FVIII Assays.

Thrombosis and haemostasis - 1 Jan 2021

Strålfors Annelie, Mikovic Danijela, Schmidt David, Onelöv Liselotte, Soutari Nida Mahmoud Hourani, Berndtson Maria, Chaireti Roza, Holmström Margareta, Antovic Jovan P, Bruzelius Maria

Abstract excerpt

BACKGROUND: Factor VIII (FVIII) activity (FVIII:C) can be measured by different methods including one-stage clotting assays (OSAs) and chromogenic assays (CSAs). Discrepancy between FVIII:C assays is known and associated with genetic variations causing mild and moderate hemophilia A (HA). We aimed to study the discrepancy phenomenon and to identify associated genetic alterations. Further, we investigated if...

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PMID: 32791533
DOI: 10.1055/s-0040-1715443

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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