Article
One-stage and chromogenic FVIII:C assay discrepancy in mild haemophilia A and the relationship with the mutation and bleeding phenotype.
Haemophilia : the official journal of the World Federation of Hemophilia - 1 Sept 2008
Cid A R, Calabuig M, Cortina V, Casaña P, Haya S, Moret A, Cabrera N, Aznar J A
Abstract excerpt
The discrepancy of the levels of factor VIII activity (FVIII:C) by different assays in some mild and moderate haemophilic A patients has been long known. Specific mutations affecting FVIII:C discrepancies have been described. No consensus exit as to which method most accurately represents the FVIII cofactor function in vivo and which has a better correlation with the haemorrhagic clinical expression. We studied...
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