Sequence variants associated with BMI affect disease risk through BMI itself.

doi:10.1038/s41467-024-53568-9

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Article

Sequence variants associated with BMI affect disease risk through BMI itself.

Nature communications - 12 Nov 2024

Einarsson Gudmundur, Thorleifsson Gudmar, Steinthorsdottir Valgerdur, Zink Florian, Helgason Hannes, Olafsdottir Thorhildur, Rognvaldsson Solvi, Tragante Vinicius, Ulfarsson Magnus O, Sveinbjornsson Gardar, Snaebjarnarson Audunn S, Einarsson Hafsteinn, Aegisdottir Hildur M, Jonsdottir Gudrun A, Helgadottir Anna, Gretarsdottir Solveig, Styrkarsdottir Unnur, Arnason Hannes K, Bjarnason Ragnar, Sigurdsson Emil, Arnar David O, Bjornsson Einar S, Palsson Runolfur, Bjornsdottir Gyda, Stefansson Hreinn, Thorgeirsson Thorgeir, Sulem Patrick, Thorsteinsdottir Unnur, Holm Hilma, Gudbjartsson Daniel F, Stefansson Kari

Abstract excerpt

Mendelian Randomization studies indicate that BMI contributes to various diseases, but it's unclear if this is entirely mediated by BMI itself. This study examines whether disease risk from BMI-associated sequence variants is mediated through BMI or other mechanisms, using data from Iceland and the UK Biobank. The associations of BMI genetic risk score with diseases like fatty liver disease, knee replacement, and...

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PMID: 39532837
DOI: 10.1038/s41467-024-53568-9
PMCID: PMC11557886

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