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A novel label-free impedance biosensor for KRAS G12C mutations detection based on PET-RAFT and ROP synergistic signal amplification.

Bioelectrochemistry (Amsterdam, Netherlands) - 1 Feb 2025

Zhang Yaping, Wei Haiyan, Guo Liang, Gao Wei, Cheng Di, Liu Yanju

Abstract excerpt

The KRAS G12C mutations, as crucial biomarkers, are closely associated with non-small cell lung cancer. Here, a novel label-free electrochemical biosensor with synergistic signal amplification of photocell energy transfer-reversible addition fragmentation chain transfer (PET-RAFT) and ring-opening polymerization (ROP) was developed for the first time for sensitive detection of KRAS G12C mutations. Specifically,...

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PMID: 39531994
DOI: 10.1016/j.bioelechem.2024.108844

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