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Article

Mitochondrial transplantation following cardiopulmonary resuscitation improves neurological function in rats by inducing M2-type MG/MΦ polarization.

Journal of translational medicine - 11 Nov 2024

Zhu Jie, Wang Zhen, Xu Mengda, Ma Xuyuan, Shen Maozheng, Yan Jingyu, Zhou Xiang

Abstract excerpt

AIM: Explore the effects of mitochondrial transplantation (MT) after cardiopulmonary resuscitation (CPR) on the polarization of microglia/macrophages (MG/MΦ) and neurological function. METHODS: Seventy-five Sprague-Dawley rats were randomly divided into five groups: sham, normal saline (NS), vehicle, mitochondria (Mito), and non-functional mitochondria (N-Mito) group. Rats in sham group underwent surgical...

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Identifiers

PMID: 39529087
DOI: 10.1186/s12967-024-05815-2
PMCID: PMC11552134

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TNF

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