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Article

Quercetin prevents necroptosis of oligodendrocytes by inhibiting macrophages/microglia polarization to M1 phenotype after spinal cord injury in rats.

Journal of neuroinflammation - 7 Nov 2019

Fan Hong, Tang Hai-Bin, Shan Le-Qun, Liu Shi-Chang, Huang Da-Geng, Chen Xun, Chen Zhe, Yang Ming, Yin Xin-Hua, Yang Hao, Hao Ding-Jun

Abstract excerpt

BACKGROUND: Oligodendrocytes (OLs) death after spinal cord injury (SCI) contributes to demyelination, even leading to a permanent neurological deficit. Besides apoptosis, our previous study demonstrated that OLs underwent receptor-interacting serine-threonine kinase 3(RIP3)/mixed lineage kinase domain-like protein (MLKL)-mediated necroptosis. Considering that necroptosis is always accompanied with...

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Identifiers

PMID: 31699098
DOI: 10.1186/s12974-019-1613-2
PMCID: PMC6839267

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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