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Article

Neighboring mutation-mediated enhancement of dengue virus infectivity and spread.

EMBO reports - 7 Nov 2022

Chen Lu, Zhang Xianwen, Guo Xuan, Peng Wenyu, Zhu Yibin, Wang Zhaoyang, Yu Xi, Shi Huicheng, Li Yuhan, Zhang Liming, Wang Lei, Wang Penghua, Cheng Gong

Abstract excerpt

Frequent turnover of dengue virus (DENV) clades is one of the major forces driving DENV persistence and prevalence. In this study, we assess the fitness advantage of nine stable substitutions within the envelope (E) protein of DENV serotypes. Two tandem neighboring substitutions, threonine to lysine at the 226th (T226K) and glycine to glutamic acid at the 228th (G228E) residues in the DENV2 Asian I genotype,...

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Identifiers

PMID: 36197120
DOI: 10.15252/embr.202255671
PMCID: PMC9638853

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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