Article
Evolution of dengue virus type 2 during two consecutive outbreaks with an increase in severity in southern Taiwan in 2001-2002.
The American journal of tropical medicine and hygiene - 1 Oct 2008
Chen Hui-Ling, Lin Su-Ru, Liu Hsin-Fu, King Chwan-Chuen, Hsieh Szu-Chia, Wang Wei-Kung
Abstract excerpt
To investigate viral determinants and evolution linked to outbreak with increased severity, we examined dengue virus type 2 (DENV-2) sequences from plasma of 31 patients (14 dengue fever, 17 dengue hemorrhagic fever, DHF) continuously during the 2001 and 2002 outbreaks in southern Taiwan, in which both the total cases and proportion of DHF cases increased. Analysis of envelope (E) and full-genome sequences...
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