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Intra-epidemic evolutionary dynamics of a Dengue virus type 1 population reveal mutant spectra that correlate with disease transmission.

Scientific reports - 4 Mar 2016

Hapuarachchi Hapuarachchige Chanditha, Koo Carmen, Kek Relus, Xu Helen, Lai Yee Ling, Liu Lilac, Kok Suet Yheng, Shi Yuan, Chuen Raphael Lee Tze, Lee Kim-Sung, Maurer-Stroh Sebastian, Ng Lee Ching

Abstract excerpt

Dengue virus (DENV) is currently the most prevalent mosquito-borne viral pathogen. DENVs naturally exist as highly heterogeneous populations. Even though the descriptions on DENV diversity are plentiful, only a few studies have narrated the dynamics of intra-epidemic virus diversity at a fine scale. Such accounts are important to decipher the reciprocal relationship between viral evolutionary dynamics and disease...

Topics

Antigenic Variation
Antigens, Viral
Biological Evolution
Dengue
Dengue Virus
Epidemics
Evolution, Molecular
Genetic Variation
Genotype
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Phylogeny

RNA, Viral

Risk

Sequence Analysis, DNA

Source

Open in PubMed Open full text

Identifiers

PMID: 26940650
DOI: 10.1038/srep22592
PMCID: PMC4778070

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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