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Article

microRNA-18a-5p promotes vascular smooth muscle cell phenotypic switch by targeting Notch2 as therapeutic targets in vein grafts restenosis.

European journal of pharmacology - 15 Dec 2024

Zhan Xu, Zhong Chang-Ming, Tang Hao, Xiao Hansong, Guo Yongzheng, Zhang Cheng, Qu Can, Wang Xiaowen, Huang Chun

Abstract excerpt

Vascular smooth muscle cells (VSMCs) phenotype switching plays a crucial role in vein graft restenosis following coronary artery bypass grafting (CABG) surgery. To discover novel clinically relevant therapeutic targets for vein graft restenosis after CABG, we therefore investigated whether miRNA-18a-5p mediated phenotype switching plays a critical role in the development of vein graft restenosis. We studied...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 39522684
DOI: 10.1016/j.ejphar.2024.177097

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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