Article
Hif-1α/Slit2 Mediates Vascular Smooth Muscle Cell Phenotypic Changes in Restenosis of Bypass Grafts.
Journal of cardiovascular translational research - 1 Oct 2023
Li Sen, Gao Zhiwei, Li Haiqing, Xu Chang, Chen Bing, Zha Qing, Yang Ke, Wang Weilin
Abstract excerpt
Vascular smooth muscle cells (VSMCs) are involved in restenosis of bypass grafts and cause artery graft occlusion. This study aimed to explore the role of Slit2 in phenotypic switching of VSMCs and its effect on restenosis of vascular conduits. An animal model of vascular graft restenosis (VGR) was produced in SD rats and assessed by echocardiography. The expression of Slit2 and Hif-1α was measured in vivo and in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
