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Article

Genetic Progression of Pancreatic Cancer

1 Jan 2014

Abstract excerpt

The progression from normal cells to invasive pancreatic ductal adenocarcinoma (PDAC) requires the accumulation of multiple inherited or acquired mutations. Activating point mutations in the KRAS oncogene are prevalent in pancreatic cancer and result in the stimulation of several pathways including the RAF-mitogen-activated protein kinase pathway and the phosphoinositide 3-kinase pathway. Other genetic...

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PMID: 24445769
DOI: 10.1097/ppo.0000000000000011

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