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Identification of evolutionary mechanisms of myelomatous effusion by single-cell RNA sequencing

5 Jun 2023

Abstract excerpt

Myelomatous effusion (ME) is a rare manifestation of extramedullary multiple myeloma (MM) with limited therapeutic options and poor outcomes. The molecular mechanisms underlying ME are incompletely understood. We profiled transcriptomes of bone marrow, peripheral blood (PB), and pleural effusion/ascites from 3 patients with ME using single-cell RNA sequencing analysis. We found that ME contained a higher...

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PMID: 37276129
DOI: 10.1182/bloodadvances.2022009477

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