Article
Uncovering cell-type-specific immunomodulatory variants and molecular phenotypes in COVID-19 using structurally resolved protein networks.
Cell reports - 26 Nov 2024
Chhibbar Prabal, Guha Roy Priyamvada, Harioudh Munesh K, McGrail Daniel J, Yang Donghui, Singh Harinder, Hinterleitner Reinhard, Gong Yi-Nan, Yi S Stephen, Sahni Nidhi, Sarkar Saumendra N, Das Jishnu
Abstract excerpt
Immunomodulatory variants that lead to the loss or gain of specific protein interactions often manifest only as organismal phenotypes in infectious disease. Here, we propose a network-based approach to integrate genetic variation with a structurally resolved human protein interactome network to prioritize immunomodulatory variants in COVID-19. We find that, in addition to variants that pass genome-wide...
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