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Article

Slc20a1b is essential for hematopoietic stem/progenitor cell expansion in zebrafish.

Science China. Life sciences - 1 Dec 2021

Chen Jiakui, Li Gaofei, Lian Junwei, Ma Ning, Huang Zhibin, Li Jianchao, Wen Zilong, Zhang Wenqing, Zhang Yiyue

Abstract excerpt

Hematopoietic stem and progenitor cells (HSPCs) are able to self-renew and can give rise to all blood lineages throughout their lifetime, yet the mechanisms regulating HSPC development have yet to be discovered. In this study, we characterized a hematopoiesis defective zebrafish mutant line named smu07, which was obtained from our previous forward genetic screening, and found the HSPC expansion deficiency in the...

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PMID: 33751369
DOI: 10.1007/s11427-020-1878-8

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