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Article

Associations of human blood metabolome with optic neurodegenerative diseases: a bi-directionally systematic mendelian randomization study.

Lipids in health and disease - 4 Nov 2024

Tong Bin, Long Chubing, Zhang Jing, Zhang Xin, Li Zhengyang, Qi Haodong, Su Kangtai, Zhang Deju, Chen Yixuan, Ling Jitao, Liu Jianping, Hu Yunwei, Yu Peng

Abstract excerpt

BACKGROUND: Metabolic disruptions were observed in patients with optic neurodegenerative diseases (OND). However, evidence for the causal association between metabolites and OND is limited. METHODS: Two-sample Mendelian randomization (MR). Summary data for 128 blood metabolites was selected from three genome-wide association study (GWASs) involving 147,827 participants of European descent. GWASs Data for glaucoma...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39497194
DOI: 10.1186/s12944-024-02337-0
PMCID: PMC11533396

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