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Functional analysis of a S-adenosylmethionine-insensitive methylenetetrahydrofolate reductase identified in methionine-accumulating yeast mutants.

Bioscience, biotechnology, and biochemistry - 23 Dec 2024

Isogai Shota, Nishimura Akira, Inoue Akiko, Sonohara Shino, Tsugukuni Takashi, Takagi Hiroshi

Abstract excerpt

Essential amino acids (EAAs) are important for the maintenance of brain functions. Therefore, the yeast Saccharomyces cerevisiae that accumulates EAAs would help elderly people ingest appropriate levels of EAAs, which in turn could slow neurodegeneration, extend the healthy lifespan, and improve quality of life. Here, we isolated 2 mutant strains, ETH-80 and ETH-129, that accumulate the EAA methionine. Both...

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PMID: 39496525
DOI: 10.1093/bbb/zbae154

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