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Article

Functional characterization of human methylenetetrahydrofolate reductase in Saccharomyces cerevisiae.

The Journal of biological chemistry - 12 Nov 1999

Shan X, Wang L, Hoffmaster R, Kruger W D

Abstract excerpt

Human methylenetetrahydrofolate reductase (MTHFR, EC 1.5.1.20) catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. 5-Methyltetrahydrofolate is a major methyl donor in the remethylation of homocysteine to methionine. Impaired MTHFR can cause high levels of homocysteine in plasma, which is an independent risk factor for vascular disease and neural tube defects. We have...

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Source

Identifiers

PMID: 10551815
DOI: 10.1074/jbc.274.46.32613

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functional characterization of human methylenetetrahydrofolate reductase in Saccharomyces cerevisiae.PMID 10551815Read ↗

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