Article
Spatial organization of PI3K-PI(3,4,5)P3-AKT signaling by focal adhesions.
Molecular cell - 21 Nov 2024
Wang Jing, An Zhengyang, Wu Zhongsheng, Zhou Wei, Sun Pengyu, Wu Piyu, Dang Song, Xue Rui, Bai Xue, Du Yongtao, Chen Rongmei, Wang Wenxu, Huang Pei, Lam Sin Man, Ai Youwei, Liu Suling, Shui Guanghou, Zhang Zhe, Liu Zheng, Huang Jianyong, Fang Xiaohong, He Kangmin
Abstract excerpt
The class I phosphatidylinositol 3-kinase (PI3K)-AKT signaling pathway is a key regulator of cell survival, growth, and proliferation and is among the most frequently mutated pathways in cancer. However, where and how PI3K-AKT signaling is spatially activated and organized in mammalian cells remains poorly understood. Here, we identify focal adhesions (FAs) as subcellular signaling hubs organizing the activation...
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