Article
Genomic landscape of Ewing sarcoma defines an aggressive subtype with co-association of STAG2 and TP53 mutations.
Cancer discovery - 1 Nov 2014
Tirode Franck, Surdez Didier, Ma Xiaotu, Parker Matthew, Le Deley Marie Cécile, Bahrami Armita, Zhang Zhaojie, Lapouble Eve, Grossetête-Lalami Sandrine, Rusch Michael, Reynaud Stéphanie, Rio-Frio Thomas, Hedlund Erin, Wu Gang, Chen Xiang, Pierron Gaelle, Oberlin Odile, Zaidi Sakina, Lemmon Gordon, Gupta Pankaj, Vadodaria Bhavin, Easton John, Gut Marta, Ding Li, Mardis Elaine R, Wilson Richard K, Shurtleff Sheila, Laurence Valérie, Michon Jean, Marec-Bérard Perrine, Gut Ivo, Downing James, Dyer Michael, Zhang Jinghui, Delattre Olivier
Abstract excerpt
UNLABELLED: Ewing sarcoma is a primary bone tumor initiated by EWSR1-ETS gene fusions. To identify secondary genetic lesions that contribute to tumor progression, we performed whole-genome sequencing of 112 Ewing sarcoma samples and matched germline DNA. Overall, Ewing sarcoma tumors had relatively few single-nucleotide variants, indels, structural variants, and copy-number alterations. Apart from whole...
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