Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals.

Current genetics - 1 Mar 1995

Prasad R, De Wergifosse P, Goffeau A, Balzi E

Abstract excerpt

By functional complementation of a PDR5 null mutant of Saccharomyces cerevisiae, we have cloned and sequenced the multidrug-resistance gene CDR1 of Candida albicans. Transformation by CDR1 of a PDR5-disrupted host hypersensitive to cycloheximide and chloramphenicol resulted in resistance to cycloheximide, chloramphenicol and other drugs, such as the antifungal miconazole, with collateral hypersensitivity to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence
Share to Cloning, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fungal Proteins

Share to Molecular Sequence Data

Share to Mutation

Share to Restriction Mapping

Share to Saccharomyces cerevisiae

Source

Identifiers

PMID: 7614555
DOI: 10.1007/BF00352101

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals.PMID 7614555Read ↗

All about CDR transporters: Past, present, and futureSemantic proximity Read ↗

Functional expression of Candida albicans drug efflux pump Cdr1p in a Saccharomyces cerevisiae strain deficient in membrane transporters.Semantic proximity Read ↗

The ABCs of Candida albicans Multidrug Transporter Cdr1Semantic proximity Read ↗

Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter geneSemantic proximity Read ↗

Update on the structure and function of Candida albicans drug efflux protein, Cdr1Semantic proximity Read ↗

Engineering a Cysteine-Deficient Functional Candida albicans Cdr1 Molecule Reveals a Conserved Region at the Cytosolic Apex of ABCG Transporters Important for Correct Folding and Trafficking of Cdr1.Semantic proximity Read ↗

RNA sequencing revealed novel actors of the acquisition of drug resistance in Candida albicansSemantic proximity Read ↗

Functional characterization of Candida albicans ABC transporter Cdr1p.Semantic proximity Read ↗

The DNA-binding domain of CaNdt80p is required to activate CDR1 involved in drug resistance in Candida albicans.Semantic proximity Read ↗

Atomic modelling and systematic mutagenesis identify residues in multiple drug binding sites that are essential for drug resistance in the major Candida transporter Cdr1.Semantic proximity Read ↗

Multidrug resistance in fungi: regulation of transporter-encoding gene expressionSemantic proximity Read ↗

Identification and Expression of Multidrug Transporters Responsible for Fluconazole Resistance in Candida dubliniensisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.