Article
Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals.
Current genetics - 1 Mar 1995
Prasad R, De Wergifosse P, Goffeau A, Balzi E
Abstract excerpt
By functional complementation of a PDR5 null mutant of Saccharomyces cerevisiae, we have cloned and sequenced the multidrug-resistance gene CDR1 of Candida albicans. Transformation by CDR1 of a PDR5-disrupted host hypersensitive to cycloheximide and chloramphenicol resulted in resistance to cyclo...
Topics
- Amino Acid Sequence
- Antifungal Agents
- Base Sequence
- Candida albicans
- Cloning, Molecular
- Drug Resistance, Multiple
- Fungal Proteins
- Membrane Transport Proteins
- Models, Biological
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Restriction Mapping
- Saccharomyces cerevisiae
- Sequence Alignment
- Transformation, Genetic