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Article

PARP15 Is a Susceptibility Locus for Clarkson Disease (Monoclonal Gammopathy-Associated Systemic Capillary Leak Syndrome).

Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 2024

Chan Eunice C, Ablooglu Ararat J, Ghosh Chandra C, Desai Abhishek, Schaible Niccole, Chen Xiuying, Zhao Ming, Olano M Renee, Ganesan Sundar, Lack Justin B, Krishnan Ramaswamy, Parikh Samir M, Druey Kirk M

Abstract excerpt

BACKGROUND: Vascular leakage is a deadly complication of severe infections, ranging from bacterial sepsis to malaria. Worldwide, septicemia is among the top 10 causes of lethality because of the shock and multiorgan dysfunction that arise from the host vascular response. In the monoclonal gammopathy-associated capillary leak syndrome (MG-CLS), even otherwise mundane infections induce recurrent septic-like...

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Identifiers

PMID: 39479769
DOI: 10.1161/ATVBAHA.124.321522
PMCID: PMC11602389

Genes

PARP15

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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