Article

Disruption of the VEGFR3–HSPG2 induces lymphatic reflux dysfunction and sepsis

2026-01-29

Abstract excerpt

The lymphatic system plays a central role in fluid transport and immune regulation, yet its contribution to sepsis remains incompletely understood. Analysis of more than 500,000 individuals from the UK Biobank reveals that lymphatic system disorders and genetic variants in FLT4 (VEGFR3) are strongly associated with increased sepsis risk. Single-cell RNA sequencing further shows a marked reduction of VEGFR3^high ly...

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Literature Corpus work: 5bbb3521-38c6-5436-b6b6-a371010bc0b1
DOI: 10.64898/2026.01.28.702461

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