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The M Type K15 Protein of Kaposi's Sarcoma-Associated Herpesvirus Regulates MicroRNA Expression via Its SH2-Binding Motif To Induce Cell Migration and Invasion

30 Oct 2008

Abstract excerpt

Kaposi's sarcoma (KS) associated herpesvirus (KSHV) is the etiological agent of KS. In vivo, KS is a tumor capable of spreading throughout the body, and pulmonary metastasis is observed clinically. In vitro, KSHV induces the invasiveness of endothelial cells. The KSHV open reading frame K15 is a KSHV-specific gene encoding a transmembrane protein. Two highly divergent forms of K15, the predominant (P) and minor...

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Identifiers

PMID: 18971265
DOI: 10.1128/jvi.00869-08

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The M Type K15 Protein of Kaposi's Sarcoma-Associated Herpesvirus Regulates MicroRNA Expression via Its SH2-Binding Motif To Induce Cell Migration and InvasionPMID 18971265Read ↗

Functional characterization of the M-type K15-encoded membrane protein of Kaposi's sarcoma-associated herpesvirus.Semantic proximity Read ↗

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Identification of the novel K15 gene at the rightmost end of the Kaposi's sarcoma-associated herpesvirus genome.Semantic proximity Read ↗

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The manipulation of miRNA-gene regulatory networks by KSHV induces endothelial cell motilitySemantic proximity Read ↗

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Oncovirus Kaposi Sarcoma Herpesvirus (KSHV) Represses Tumor Suppressor PDLIM2 to Persistently Activate Nuclear Factor κB (NF-κB) and STAT3 Transcription Factors for Tumorigenesis and Tumor MaintenanceSemantic proximity Read ↗

Oncogenic KSHV-encoded interferon regulatory factor upregulates HMGB2 and CMPK1 expression to promote cell invasion by disrupting a complex lncRNA-OIP5-AS1/miR-218-5p networkSemantic proximity Read ↗

The Oncogenic Kaposi’s Sarcoma-Associated Herpesvirus Encodes a Mimic of the Tumor-Suppressive miR-15/16 miRNA FamilySemantic proximity Read ↗

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