Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MEK inhibition reduced vascular tumor growth and coagulopathy in a mouse model with hyperactive GNAQ.

Nature communications - 6 Apr 2023

Schrenk Sandra, Bischoff Lindsay J, Goines Jillian, Cai Yuqi, Vemaraju Shruti, Odaka Yoshinobu, Good Samantha R, Palumbo Joseph S, Szabo Sara, Reynaud Damien, Van Raamsdonk Catherine D, Lang Richard A, Boscolo Elisa

Abstract excerpt

Activating non-inherited mutations in the guanine nucleotide-binding protein G(q) subunit alpha (GNAQ) gene family have been identified in childhood vascular tumors. Patients experience extensive disfigurement, chronic pain and severe complications including a potentially lethal coagulopathy termed Kasabach-Merritt phenomenon. Animal models for this class of vascular tumors do not exist. This has severely...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endothelial Cells

Share to GTP-Binding Protein alpha Subunits

Share to GTP-Binding Protein alpha Subunits, Gq-G11

Share to Melanoma

Share to Mitogen-Activated Protein Kinase Kinases

Share to Uveal Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 37024491
DOI: 10.1038/s41467-023-37516-7
PMCID: PMC10079932

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MEK inhibition reduced vascular tumor growth and coagulopathy in a mouse model with hyperactive GNAQ.PMID 37024491Read ↗

Calcineurin-NFAT-DSCR1.4 signaling as druggable axis in Gαq-R183Q-driven capillary malformations.Semantic proximity Read ↗

Phosphoproteomics Maps Calcineurin-NFAT-DSCR1.4 Signaling as Druggable Axis in Gαq-R183Q–Driven Capillary MalformationsSemantic proximity Read ↗

Endothelial GNAQ p.R183Q Increases ANGPT2 (Angiopoietin-2) and Drives Formation of Enlarged Blood Vessels.Semantic proximity Read ↗

Hyperactive GNAQ in endothelial cells causes blood vessel malformation in developing mouse skin.Semantic proximity Read ↗

Somatic Loss-of-Function PIK3R1 and Activating Non-hotspot PIK3CA Mutations Associated with Capillary Malformation with Dilated Veins (CMDV)Semantic proximity Read ↗

GNA14 Somatic Mutation Causes Congenital and Sporadic Vascular Tumors by MAPK Activation.Semantic proximity Read ↗

MAPK Signaling and Angiopoietin-2 Contribute to Endothelial Permeability in Capillary MalformationsSemantic proximity Read ↗

GNA14 and GNAQ somatic mutations cause spinal and intracranial extra-axial cavernous hemangiomas.Semantic proximity Read ↗

RAS Pathway Mutations and Therapeutics in Vascular Anomalies.Semantic proximity Read ↗

GNA14, GNA11, and GNAQ Mutations Are Frequent in Benign but Not Malignant Cutaneous Vascular TumorsSemantic proximity Read ↗

An endothelial specific mouse model for the capillary malformation mutation Gnaq p.R183Q.Semantic proximity Read ↗

GNAQ mutations drive port wine birthmark-associated Sturge-Weber syndrome: A review of pathobiology, therapies, and current modelsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.