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Article

Discovery of dual function acridones as a new antimalarial chemotype.

Nature - 14 May 2009

Kelly Jane X, Smilkstein Martin J, Brun Reto, Wittlin Sergio, Cooper Roland A, Lane Kristin D, Janowsky Aaron, Johnson Robert A, Dodean Rozalia A, Winter Rolf, Hinrichs David J, Riscoe Michael K

Abstract excerpt

Preventing and delaying the emergence of drug resistance is an essential goal of antimalarial drug development. Monotherapy and highly mutable drug targets have each facilitated resistance, and both are undesirable in effective long-term strategies against multi-drug-resistant malaria. Haem remai...

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Identifiers

PMID: 19357645
DOI: 10.1038/nature07937
PMCID: PMC8158239

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19357645-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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