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Article

Changing the metal binding specificity of superoxide dismutase from Thermus thermophilus HB-27 by a single mutation.

Molecular biotechnology - 1 Jun 2009

Wang Tianwen, Qiu Aidong, Meng Fanguo, Zhou Haimeng

Abstract excerpt

Metal binding of superoxide dismutase from Thermus thermophilus HB27 was analyzed by comparing the related structures and sequences from different origins. Mutants (Ile166Leu, Asp167Glu, and Ile166Leu-Asp167Glu) were prepared and characterized. The mutants Asp167Glu and Ile166Leu-Asp167Glu changed their binding specificities from manganese to iron, which were manifested by the differences in color of the enzyme...

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Source

Identifiers

PMID: 19191037
DOI: 10.1007/s12033-009-9149-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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