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Article

Brain temperature, brain metabolites, and immune system phenotypes in temporal lobe epilepsy.

Epilepsia open - 1 Dec 2024

Mueller Christina, Hong Huixian, Sharma Ayushe A, Qin Hongwei, Benveniste Etty N, Szaflarski Jerzy P

Abstract excerpt

OBJECTIVE: Epileptogenesis is linked to neuroinflammation. We hypothesized that local heat production caused by neuroinflammation can be visualized non-invasively in vivo via brain magnetic resonance spectroscopic imaging (MRSI) and MRSI-thermometry (MRSI-t) and that there is a relationship in patients with temporal lobe epilepsy (TLE) between MRSI-t and brain metabolites choline and myo-inositol and between...

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Identifiers

PMID: 39470707
DOI: 10.1002/epi4.13082
PMCID: PMC11633690

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