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Article

Obesity-dependent selection of driver mutations in cancer.

Nature genetics - 1 Nov 2024

Tang Cerise, Castillon Venise Jan, Waters Michele, Fong Chris, Park Tricia, Boscenco Sonia, Kim Susie, Pekala Kelly, Carrot-Zhang Jian, Hakimi A Ari, Schultz Nikolaus, Ostrovnaya Irina, Gusev Alexander, Jee Justin, Reznik Ed

Abstract excerpt

Obesity is a risk factor for cancer, but whether obesity is linked to specific genomic subtypes of cancer is unknown. We examined the relationship between obesity and tumor genotype in two clinicogenomic corpora. Obesity was associated with specific driver mutations in lung adenocarcinoma, endometrial carcinoma and cancers of unknown primaries, independent of clinical covariates, demographic factors and genetic...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 39468367
DOI: 10.1038/s41588-024-01969-3
PMCID: PMC11549034

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