Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Role of Mendelian Randomization Studies in Deciphering the Effect of Obesity on Cancer.

Journal of the National Cancer Institute - 8 Mar 2022

Fang Zhe, Song Mingyang, Lee Dong Hoon, Giovannucci Edward L

Abstract excerpt

Associations of obesity have been established for at least 11 cancer sites in observational studies, though some questions remain as to causality, strength of associations, and timing of associations throughout the life course. In recent years, Mendelian randomization (MR) has provided complementary information to traditional approaches, but the validity requires that the genetic instrumental variables be...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adiposity
Share to Body Mass Index
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Causality

Share to Genome-Wide Association Study

Share to Mendelian Randomization Analysis

Share to Obesity

Share to Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 34021349
DOI: 10.1093/jnci/djab102
PMCID: PMC8902442

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Role of Mendelian Randomization Studies in Deciphering the Effect of Obesity on Cancer.PMID 34021349Read ↗

Body fatness associations with cancer: evidence from recent epidemiological studies and future directionsSemantic proximity Read ↗

Applying Mendelian randomization to appraise causality in relationships between nutrition and cancerSemantic proximity Read ↗

Mendelian randomization study of adiposity-related traits and risk of breast, ovarian, prostate, lung and colorectal cancer.Semantic proximity Read ↗

Causal association of childhood obesity with cancer risk in adulthood: A Mendelian randomization study.Semantic proximity Read ↗

Novel insights into the consequences of obesity: a phenotype-wide Mendelian randomization study.Semantic proximity Read ↗

Causal role of high body mass index in multiple chronic diseases: a systematic review and meta-analysis of Mendelian randomization studies.Semantic proximity Read ↗

Causal inference in cancer epidemiology: what is the role of Mendelian randomization?Semantic proximity Read ↗

A Review of Mendelian Randomization: Assumptions, Methods, and Application to Obesity-Related DiseasesSemantic proximity Read ↗

Reassessing the causal role of obesity in breast cancer susceptibility: a comprehensive multivariable Mendelian randomization investigating the distribution and timing of exposure.Semantic proximity Read ↗

Advances in Mendelian Randomization Studies of Obesity Over the Past Decade: Uncovering Key Genetic MechanismsSemantic proximity Read ↗

Visceral and ectopic fat are more predictively associated with primary liver cancer than overall obesity from genetic sights: A Mendelian randomization study.Semantic proximity Read ↗

Assessment of causal effects of visceral adipose tissue on risk of cancers: a Mendelian randomization study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.