Article
Shared Genetic Etiology of Obesity-Related Traits and Barrett's Esophagus/Adenocarcinoma: Insights from Genome-Wide Association Studies.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Feb 2020
Böhmer Anne C, Hecker Julian, Schröder Julia, Gharahkhani Puya, May Andrea, Gerges Christian, Anders Mario, Becker Jessica, Hess Timo, Kreuser Nicole, Thieme René, Noder Tania, Venerito Marino, Veits Lothar, Schmidt Thomas, Fuchs Claudia, Izbicki Jakob R, Hölscher Arnulf H, Dietrich Arne, Moulla Yusef, Lyros Orestis, Lang Hauke, Lorenz Dietmar, Schumacher Brigitte, Mayershofer Rupert, Vashist Yogesh, Ott Katja, Vieth Michael, Weismüller Josef, Moebus Susanne, Knapp Michael, Neuhaus Horst, Rösch Thomas, Ell Christian, Nöthen Markus M, Whiteman David C, Tomlinson Ian, Jankowski Janusz, Fitzgerald Rebecca C, Palles Claire, Vaughan Thomas L, Gockel Ines, Thrift Aaron P, Fier Heide, Schumacher Johannes
Abstract excerpt
BACKGROUND: Obesity is a major risk factor for esophageal adenocarcinoma (EA) and its precursor Barrett's esophagus (BE). Research suggests that individuals with high genetic risk to obesity have a higher BE/EA risk. To facilitate understanding of biological factors that lead to progression from BE to EA, the present study investigated the shared genetic background of BE/EA and obesity-related traits. METHODS:...
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