Article
Tissue-specific genetic variation suggests distinct molecular pathways between body shape phenotypes and colorectal cancer.
Science advances - 19 Apr 2024
Peruchet-Noray Laia, Sedlmeier Anja M, Dimou Niki, Baurecht Hansjörg, Fervers Béatrice, Fontvieille Emma, Konzok Julian, Tsilidis Kostas K, Christakoudi Sofia, Jansana Anna, Cordova Reynalda, Bohmann Patricia, Stein Michael J, Weber Andrea, Bézieau Stéphane, Brenner Hermann, Chan Andrew T, Cheng Iona, Figueiredo Jane C, Garcia-Etxebarria Koldo, Moreno Victor, Newton Christina C, Schmit Stephanie L, Song Mingyang, Ulrich Cornelia M, Ferrari Pietro, Viallon Vivian, Carreras-Torres Robert, Gunter Marc J, Freisling Heinz
Abstract excerpt
It remains unknown whether adiposity subtypes are differentially associated with colorectal cancer (CRC). To move beyond single-trait anthropometric indicators, we derived four multi-trait body shape phenotypes reflecting adiposity subtypes from principal components analysis on body mass index, height, weight, waist-to-hip ratio, and waist and hip circumference. A generally obese (PC1) and a tall, centrally obese...
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