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Article

Molecular signatures of N-nitroso compounds in Caco-2 cells: implications for colon carcinogenesis.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Apr 2009

Hebels Dennie G A J, Jennen Danyel G J, Kleinjans Jos C S, de Kok Theo M C M

Abstract excerpt

N-nitroso compounds (NOC) are genotoxic, carcinogenic to animals, and may play a role in human cancer development. Because the gastro-intestinal tract is an important route of exposure through endogenous nitrosation, we hypothesize that NOC exposure targets genetic processes relevant in colon carcinogenesis. To investigate these genomic responses, we analyzed the transcriptomic effects of genotoxic concentrations...

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Identifiers

PMID: 19221148
DOI: 10.1093/toxsci/kfp035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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