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Multidimensional bioinformatics analysis reveals the potential carcinogenic role of acrylamide in colorectal cancer

10 May 2025

Abstract excerpt

OBJECTIVE: This study aims to elucidate the molecular mechanisms underlying acrylamide-induced colorectal cancer (CRC), identify key carcinogenic genes, and investigate their roles in the immune microenvironment and gut microbiota, providing a theoretical foundation for early CRC diagnosis and prevention. METHODS: Acrylamide- and CRC-associated genes were screened from the GEO and CTDbase databases, and a Venn...

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PMID: 40347726
DOI: 10.1016/j.ecoenv.2025.118281

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