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Article

The Avoidance of Purine Stretches by Cancer Mutations.

International journal of molecular sciences - 15 Oct 2024

Vikhorev Aleksandr V, Savelev Ivan V, Polesskaya Oksana O, Rempel Michael M, Miller Richard A, Vetcher Alexandre A, Myakishev-Rempel Max

Abstract excerpt

Purine stretches, sequences of adenine (A) and guanine (G) in DNA, play critical roles in binding regulatory protein factors and influence gene expression by affecting DNA folding. This study investigates the relationship between purine stretches and cancer development, considering the aromaticity of purines, quantified by methods like Hückel's rule and NICS calculations, and the importance of the flanking...

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Identifiers

PMID: 39456831
DOI: 10.3390/ijms252011050
PMCID: PMC11507618

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