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Article

Clinical relevance of protein-truncating variants of germline DNA repair genes in prostate cancer.

BMC cancer - 25 Oct 2024

Shao Yu-Hsuan Joni, Liao Cai-Sian, Hsu Yu-Ching, Chiu Yu-Chiao, Lu Tsai-Jung, Ou Yen-Chuan, Hsiao Tzu-Hung

Abstract excerpt

BACKGROUND: Interpreting genetic variants remains a challenge in prostate cancer (PCa). Although many annotation tools are available for prioritizing causal variants, the clinical relevance of these variants is rarely studied. METHODS: We collected a cohort study that included 274 PCa patients from June 2017 to December 2020 and sequenced 19 DNA damage repair (DDR) genes in these patients and explored the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39455978
DOI: 10.1186/s12885-024-13045-4
PMCID: PMC11520037

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