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Article

Association of germline rare pathogenic mutations in guideline-recommended genes with prostate cancer progression: A meta-analysis.

The Prostate - 1 Jan 2022

Shi Zhuqing, Lu Lucy, Resurreccion William Kyle, Yang Wancai, Wei Jun, Wang Qiang, Engelmann Valentina, Zheng Siqun Lilly, Cooney Kathleen A, Isaacs William B, Helfand Brian T, Lu Jim, Xu Jianfeng

Abstract excerpt

BACKGROUND: Germline mutations in several genes, mainly DNA repair genes, have been associated with prostate cancer (PCa) progression. However, primarily due to the rarity of mutations, statistical evidence for these associations is not consistently established. The objective of this study is to synthesize evidence from multiple studies using a meta-analysis. METHODS: Genes analyzed were chosen based on National...

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PMID: 34674288
DOI: 10.1002/pros.24252

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