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Article

Chronic hypoxia for the adaptation of extracellular vesicle phenotype.

Scientific reports - 24 Oct 2024

Pridgeon Chris S, Airavaara Kerttu, Monola Julia, Jokela Alisa, Palmer Daniel, Yliperttula Marjo, Harjumäki Riina

Abstract excerpt

Variations in oxygen level affect the phenotype of cells and extracellular vesicles (EVs). Depending on the metabolic oxygen demand of cells, hypoxic cell culture can produce conditions more like those found in vivo, and with appropriate oxygen levels, mimic hypoxic tumours. However, most previous experiments studying both EVs and the effects of hypoxia on cells use periods of 72 h or less of hypoxia. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39448620
DOI: 10.1038/s41598-024-73453-1
PMCID: PMC11502752

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